Effects of sea anemone toxin anthopleurin-Q on potassium currents in rats and guinea pig ventricular myocytes / 老年心脏病学杂志（英文版）

To investigate the effect of sea anemone toxin anthopleurin-Q (AP-Q) on potassium currents in isolated rats and guinea pig ventricular myocytes.Methods The ventricular cells of guinea pigs and SD rats were obtained by enzymatic dissociation method.Whole cell patch clamp technique was used to record potassium currents (Ito,IK,and IK1).Results AP-Q 3-100 nmol/L increased Ito in a concentration-dependent manner,with an EC50 value of 12.7 nmol/L.At a potential of +50mV,AP-Q 10nmol/L increased Ito from (13.3±3.4) pA pF-1 to (19.46±4.3) pA pF-1.AP-Q 0.1-100 nmol/L increased IK and IK tail in a concentration-dependent manner with EC50 values of 4.7 nmol/L and 5.0 nmol/L,respectively.AP-Q 1 pmol/L-100 nmol/L increased IK1 in dose-dependent manner,with an EC50 of 0.2 nmol/L.Conclusions The effect of AP-Q on Ito,IK and IK1 may partly explain its mechanism in shortening APD and increasing RP.(J Geriatr Cardiol 2008;5:243-247)

Modified carroll incision for surgical treatment of idiopathic clubfoot

A prospective study was done on 20 clubfeet operated on using a modified Carroll incision, which started medially at the base of the first metatarsal extending posteriorly below the medial malleolus to the tendo-Achilles curving it anteriorly and upward posterior to the lateral malleolus with extensive posteromedial and posterolateral release. Twelve patients with 20 clubfeet, their age ranged between 3-24 months, were included in the study. Functional evaluation was used. All patients were followed up for at least one year. Eleven feet had excellent results, six feet had good results and three feet had poor results. It was found that this incision gives a better exposure of the pathoanatomy of the clubfoot, especially the posteromedial and posterolateral ligament complex with easy skin closure

Sinus tract not involving the bone after infected osteosynthesis. A case report

We present a case of sinus tract at the upper lateral part of the left thigh after open reduction and plating of fracture of the proximal femur. The patient was managed as a case of postoperative chronic osteomyelitis of the femur. The sinus discharge persisted after removal of the plate and screws. The patient recovered completely after excision of the tract without interfering with the bone